<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hundsdoerfer, A.K.</style></author><author><style face="normal" font="default" size="100%">Buchwalder, K.</style></author><author><style face="normal" font="default" size="100%">O'Neill, M.A.</style></author><author><style face="normal" font="default" size="100%">Dobler, S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical ecology traits in an adaptive radiation: TPA-sensitivity and detoxification in Hyles and Hippotion (Sphingidae, Lepidoptera) larvae</style></title><secondary-title><style face="normal" font="default" size="100%">Chemoecology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">EUPHORBIA</style></keyword><keyword><style  face="normal" font="default" size="100%">FOODPLANT CHEMISTRY</style></keyword><keyword><style  face="normal" font="default" size="100%">FOODPLANT SPECIFICITY</style></keyword><keyword><style  face="normal" font="default" size="100%">HIPPOTION</style></keyword><keyword><style  face="normal" font="default" size="100%">HYLES</style></keyword><keyword><style  face="normal" font="default" size="100%">PHORBOL ESTER</style></keyword><keyword><style  face="normal" font="default" size="100%">SPHINGIDAE</style></keyword><keyword><style  face="normal" font="default" size="100%">TETRADECANOYL-PHORBOL-13-ACETATE</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2019</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1007/s00049-018-0274-4</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">35-47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&amp;quot;The larvae of several species in the hawk moth genus &lt;em&gt;Hyles&lt;/em&gt;, including &lt;em&gt;H. euphorbiae&lt;/em&gt;, feed on plants of the genus &lt;em&gt;Euphorbia &lt;/em&gt;containing phorbol esters and are insensitive to addition of the standard phorbol ester, tetradecanoyl-phorbol-13-acetate (TPA) to their artificial diet. Specialised non-&lt;em&gt;Euphorbia &lt;/em&gt;feeding larvae were sensitive, whereas polyphagous ones were insensitive if their natural food plant spectrum also includes &lt;em&gt;Euphorbia&lt;/em&gt;. Larvae of &lt;em&gt;Hippotion celerio&lt;/em&gt;, an out-group species with polyphagous larvae not using &lt;em&gt;Euphorbia &lt;/em&gt;as food plants, were sensitive. A highly conserved sequence of the TPA binding site of the protein kinase C in &lt;em&gt;H. euphorbiae&lt;/em&gt; and &lt;em&gt;Hippotion celerio&lt;/em&gt; demonstrates that intoxication by phorbol esters is not avoided by preventing target binding. &lt;em&gt;H. euphorbiae&lt;/em&gt; larvae showed no vitality loss after chemical destruction of their peritrophic matrix and subsequent TPA treatment. TPA fed larvae that had putatively piperonyl butoxide (PBO)-inhibited cytochrome P450 enzymes also showed no deficits, indicating that this is not the only detoxification pathway in &lt;em&gt;H. euphorbiae&lt;/em&gt;. Based on these qualitative results, we postulate that proto-&lt;em&gt;Hyles &lt;/em&gt;was polyphagous with the ability to use &lt;em&gt;Euphorbia &lt;/em&gt;as food plants. The most ancestral &lt;em&gt;Hyles &lt;/em&gt;species presumably remained polyphagous, with the ability to switch to the toxic food plants if necessary. Within the youngest, Palearctic radiation, the species specialised on non-&lt;em&gt;Euphorbia &lt;/em&gt;plants subsequently lost detoxification abilities, albeit not to 100%. The species in South America, the origin of &lt;em&gt;Hyles&lt;/em&gt;, can detoxify TPA, indicating this ability to be a plesiomorphic character state within the genus that enabled its adaptive radiation in the Palearctic, the distribution and diversity centre of &lt;em&gt;Euphorbia&lt;/em&gt;.&amp;quot;&lt;/p&gt;
</style></abstract><section><style face="normal" font="default" size="100%">35</style></section></record></records></xml>